Technical details
| Product | Recombinant penicillin binding protein, PBP2x, beta-lactam receptor protein |
|---|---|
| Item # | AB5022 |
| Reactivity | Major beta-lactams including penicillins and cefalosporins, ie, penicillin, amoxicillin, cefalotin, cefatiofur, etc. |
| Conjugate | Unconjugated |
| Source | E. Coli |
| Unit Size | default size is 0.5mg, custom size is available |
| Applications | ELISA, lateral flow immunoassay |
| Format | lyophilized powder or liquid |
| Gene ID | Q9RES8 |
| Immunogen | N/A |
| Purification | Purified by ion exchange column |
| Storage | Store at -20 degree celsius or below. Shipment at room temperature. |
| Shelf Life | 12 months minimum when stored properly |
| Validated By | Internally according to ISO standards |
| Application Notes | The protein is a recombinant protein. It is only for research purpose. Please read the data sheet carefully before experiment. Dilutions shall be determined by customer in their own laboratory. The protein reacts with different penicillin at 2-30ng/ml level and cefalosporins at 10-200ng/ml level when used properly. |
PBP2x, beta-lactam receptor protein is derived from E Coli. It can be used in bioassays for the detection of beta-lactams antibiotics, including penicillin, amoxicillin, cefalotin, etc. It is highly sensitive and specific to beta-lactam groups.
Penicillin-binding proteins (PBPs) are a group of proteins that are characterized by their affinity for and binding of penicillin. They are a normal constituent of many bacteria; the name just reflects the way by which the protein was discovered. All β-lactam antibiotics (except for tabtoxinine-β-lactam, which inhibits glutamine synthetase) bind to PBPs, which are essential for bacterial cell wall synthesis. PBPs are members of a subgroup of enzymes called transpeptidases. Specifically, PBPs are DD-transpeptidases.
PBP2x belongs to PBPs and represents a primary resistance determinant for beta-lactams.
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